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AIM:To discuss the efficacy and safety of orthokeratology with reducing back optic zone diameter(5mm-BOZD)compared with conventional back optic zone diameter(6mm-BOZD)in the treatment of adolescent myopia.METHODS: A prospective randomized controlled trial was performed. There were 100 cases with 100 eyes of adolescent myopia(all right eye data were taken)selected from April 2016 to January 2019, the spherical degree was -1.00--5.00D. Then they were randomly divided into the two groups. The experimental group wore 5mm-BOZD orthokeratology, and the control group wore 6mm-BOZD orthokeratology. Their axis length(AL), spherical equivalent(SE), relative peripheral refraction(RPR), best corrected visual acuity(BCVA), uncorrected near visual acuity(NVA), Efron grading was applied to record the anterior segment of the eyes, corneal hysteresis(CH), corneal resistance factor(CRF), corneal-compensated intraocular pressure(IOPcc), average noninvasive Keratograph tear breakup time(NIKBUTav)and higher order aberration(RMSh) were compared between the two groups during the 1a treatment period.RESULTS: After 1a of treatment, the AL in experimental group increased 0.05±0.05mm,while it increased 0.15±0.05mm(t=-8.949, P<0.001)in control group. The SE in experimental group increased -0.18±0.27D,while it increased-0.42±0.35D(t=3.609, P=0.001)in control group. There were statistical differences in RPR changes at N30°, N20° and T30°sites between the two groups(P<0.05). There were no statistical differences in BCVA,NVA,Efron grade,CH,CRF,IOPcc,NIKBUTav and RMSh between the two groups(P>0.05).CONCLUSION:Reducing back optic zone diameter orthokeratology can correct adolescent myopia safely and more effectively during the observation period.
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Objective@#To evaluate the efficacy of Qinre-Jiedu-Shaoshang ointment combined with hydrophilic silver ion dressing in the treatment of deep degree Ⅱ burn.@*Methods@#A total of 89 patients with degreeⅡ burn were enrolled, and they were randomly divided into the control group (44 cases) and the treatment group (45 cases). The control group was treated with hydrophilic silver ion dressing. The treatment group was treated with Qinre-Jiedu-Shaoshang ointment combined with hydrophilic silver ion dressing. Both groups were treated continuously for 21 days. The wound healing time and dressing change times of the two groups was observed and recorded. The VAS scale was used to evaluate the degree of wound pain. The serum level of TNF-α and IL-6 were detected by ELISA.@*Results@#The total effective rate was 95.56% (43/45) in the treatment group and 77.27% (34/44) in the control group. There was a significant difference between the two groups (χ2=6.375, P=0.012). The healing time of wounds in the treatment group (17.3 ± 1.9 d vs. 22.5 ± 2.2 d, t=11.987) and dressing change times (5.1 ± 0.7 times vs. 7.4 ± 0.8 times, t=15.041) were significantly less than those in the control group (P<0.01). The VAS score of the treatment group at 7, 14 and 21 days after treatment was significantly lower than those of the control group (t values were 10.597, 19.692, 26.510, all Ps<0.001). After treatment, the level of serum TNF-α and IL-6 in the treatment group were significantly lower than those in the control group (t values were 6.412, 8.202 respectively, all Ps<0.01).@*Conclusions@#The Qinre-Jiedu-Shaoshang ointment combined with hydrophilic silver ion dressing can effectively promote wound healing, reduce the degree of wound pain, reduce the level of inflammatory cytokines, and improve clinical efficacy.
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@#AIM: To observe the adolescents with different degrees of myopia who wore orthokeratology lens for 1a were visited and discuss the influence and safety of orthokeratology for curing the adolescent myopia.<p>METHODS: Totally 158 cases of adolescent myopia(-1.00D to -8.00D)who all wore the same brand orthokeratology lens were selected from September 2016 to December 2017. Their visual quality, including aberration detection, subjective discomfort and visual quality questionnaire was observed for 1a. <p>RESULTS: After wearing orthokeratology, the patients' total RMS decreased, while the RMSh, the RMS3(including coma)and the RMS4(including spherical aberration)increased. The higher of baseline degree, the higher incidence of subjective visual discomfort, and the difference between pre-wearing and after was not statistically significant in subjective visual quality score(<i>P</i>>0.05).<p>CONCLUSION: The patients' objective visual quality decreased after wearing orthokeratology lens. However, the long-term observation revealed that the overall visual quality had no significant impact on lifelihood and learning, which indicates orthokeratology is a safe and effective mean of myopia curing.
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Objective To evaluate the efficacy of Qinre-Jiedu-Shaoshang ointment combined with hydrophilic silver ion dressing in the treatment of deep degree Ⅱ burn. Methods A total of 89 patients with degreeⅡ burn were enrolled, and they were randomly divided into the control group (44 cases) and the treatment group (45 cases). The control group was treated with hydrophilic silver ion dressing. The treatment group was treated with Qinre-Jiedu-Shaoshang ointment combined with hydrophilic silver ion dressing. Both groups were treated continuously for 21 days. The wound healing time and dressing change times of the two groups was observed and recorded. The VAS scale was used to evaluate the degree of wound pain. The serum level of TNF-α and IL-6 were detected by ELISA. Results The total effective rate was 95.56% (43/45) in the treatment group and 77.27% (34/44) in the control group. There was a significant difference between the two groups ( χ2=6.375, P=0.012). The healing time of wounds in the treatment group (17.3 ± 1.9 d vs. 22.5 ± 2.2 d, t=11.987) and dressing change times (5.1 ± 0.7 times vs. 7.4 ± 0.8 times, t=15.041) were significantly less than those in the control group (P<0.01). The VAS score of the treatment group at 7, 14 and 21 days after treatment was significantly lower than those of the control group (t values were 10.597, 19.692, 26.510, all Ps<0.001). After treatment, the level of serum TNF-α and IL-6 in the treatment group were significantly lower than those in the control group (t values were 6.412, 8.202 respectively, all Ps<0.01). Conclusions The Qinre-Jiedu-Shaoshang ointment combined with hydrophilic silver ion dressing can effectively promote wound healing, reduce the degree of wound pain, reduce the level of inflammatory cytokines, and improve clinical efficacy.
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Objective To investigate the short-term safety of raltitrexed intraperitoneal perfusion in patients with rectal cancer undergoing laparoscopic Dixon surgery.Methods Totally 175 patients with rectal cancer at the Department of Colorectal Oncological Surgery,Shengjing Hospital of China Medical University were analyzed retrospectively from June 2016 to December 2017.All the patients were divided into raltitrexed intraperitoneal perfusion group (n =89) and saline intraperitoneal peffusion group (n =86) according to whether given raltitrexed intraperitoneal perfusion or not.The hematological indexes of the two groups before operation and 3 days after operation were recorded.The postoperative exhaust time and postoperative drainage volume within 24 hours were calculated.The postoperative complications including anastomotic leakage,peritoneal irritation sign,incision infection and pulmonary infection were evaluated.Results The surgery was performed successfully in all patients.There were no significant differences in the sex (x2 =0.000,P =0.990),depth of tumor invasion (x2 =0.003,P =0.956),degree of lymph node metastasis (Z =-0.590,P =0.556),TNM stage (Z =0.081,P =0.936) or pathological type (Z =1.092,P =0.896) between the two groups.There were no significant differences in postoperative exhaust time [(75.49 ± 3.97) h vs.(74.28 ±3.46) h,t =0.479,P =0.523],postoperative drainage volume within 24 hours [(201.1 ±54.1) ml vs.(242.8±25.7) ml,t=0.338,P=0.656],anastomotic leakage (1.1％ vs.2.3％,x2 =0.351,P=0.554),peritoneal irritation sign (1.1％ vs.2.3％,x2 =0.351,P =0.554),incision infection (2.2％ vs.3.5％,x2 =0.243,P =0.622) and pulmonary infection (2.2％ vs.2.3％,x2 =0.001,P =0.972) between the two groups.Additionally,there were no significant differences in the counts of erythrocytes [(3.56 ±0.27) × 1012/L vs.(3.63 ±0.26) × 1012/L,t =0.716,P =0.152],leukocytes [(7.63 ±0.20) x 109/L vs.(8.24 ±0.26) × 109/L,t =0.176,P =0.872],blood platelets [(170.13 ±20.12) × 109/L vs.(180.18 ±21.03) × 109/L,t =0.103,P =0.975],glutamic-pyruvic transaminase [(13.25 ± 2.31) U/L vs.(13.28 ± 1.46) U/L,t =0.321,P =0.713],glutamic-oxalacetic transaminase [(16.51 ± 1.28) U/L vs.(16.23 ±2.03) U/L,t=0.131,P=0.894] and creatinine [(77.36 ±6.49) μmol/L vs.(78.39 ±6.64)μmol/L,t =0.499,P =0.519] 3 days after operation between the two groups.Conclusion Raltitrexed intraperitoneal perfusion in Dixon surgery exhibits high safety,and no significant effect on postoperative recovery.It is easy to operate and has good feasibility,which is worthy to be used in clinic.
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Objective To evaluate the efficacy and safety of autologous peripheral blood stem cell transplantation (APBSCT) in treatment of patients with decompensated hepatitis B cirrhosis.Methods Sixty two patients with decompensated hepatitis B cirrhosis admitted in Ningbo Second Hospital during January 2010 and December 2013 were enrolled in the study.Patients were randomly assigned in two groups: 50 patients in control group received comprehensive medical treatment only, and 12 patients in combination group received APBSCT on the basis of medical treatment.The levels of serum total bilirubin (TBil), albumin (Alb), alanine aminotransferase (ALT) and prothrombin time (PT) in two groups were mearsured at the 4th,12th,24th week.Overall survival (OS),progression-free survival (PFS) and complications were compared between two groups after 3 years follow-up.SPSS17.0 software was used to analyze the data.Results After APBSCT treatment, the level of Alb and PT at week 4,12 and 24 in combination group improved significantly(tAlb=-4.437,-5.210 and-6.915,tPT=12.083,11.251 and 10.640,all P<0.01),there were also significant differences between combination group and control group (tAlb=4.985, 5.565 and 6.260,tPT =-3.013、-3.727 and-3.983,all P<0.01).The 3-year OS and 3-year PFS of patients in combination group were higher than those of control group [(90.9±8.7)%vs.(60.7±7.4)%, (75.8±12.5)% vs.(47.9±7.3)%](χ2=6.887 and 5.565,P<0.05).Besides,APBSCT had more advantages than control group in reducing ascitic fluid and hepatic encephalopathy(χ2=7.992 and 4.681,P<0.05 or <0.01).Conclusion APBSCT combined with medical treatment can improve liver function and 3-year survival rate with mild adverse reaction in patients with decompensated hepatitis B cirrhosis.
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OBJECTIVE: To evaluate the pharmacokinetics characteristics and safety of antipsytrotic ziprasidone mesylate with single dose intramuscularly injected in healthy volunteers. METHODS: A total of 12 healthy Chinese volunteers(male 6 cases and female 6 cases) were received intramuscularly single dose of ziprasidone mesylate, the dosage was 10 mg.Blood samples were collected at different time after intramuscularly injection.The concentrations of ziprasidone in serum were determined by LC-MS/MS, and the pharmacokinetic parameters were calculated. RESULTS: The concentration-time curves of ziprasidone fitted to two-compartment model.The pharmacokinetic parameters were stated as follows, ρmax was (97.85± 29.24) ng·mL-1;tmax was (0.56±0.30)h;MRT was (5.35±0.96) h; t1/2 was (4.29±0.88)h; AUC0→t was (405.6±98.68) ng·h·mL-1, AUC0→∞was (413.3± 100.69)ng·h·mL-1; CL was (25.50±6.10)L·h-1; Vd was (157.48±47.60)L; Kel was (0.168±0.035)h. There were no significant differences of the parameters between the male and female subjects. The common adverse events were somnolence, nausea and weakness with the severity of mild to moderate. CONCLUSION: The pharmacokinetic parameters in 12 healthy volunteers after intramuscular injection of 10 mg ziprasidone mesylate are in line with that reported in the literature. This medicine has effect of sedation, so that it could be used to control the excited agitation.
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The container closure system is indispensable to metered-dose inhaler(MDI). In the shelf life of MDI,various in?gredients of the container closure system may become potential leachables and migrate into the preparation. Due to their unknown con?structs and latent ambiguous toxicities,leachables may significantly affect drugs′effectiveness and safety. Consequently,it is neces?sary to carry on leachable studies to ensure the good compatibility of MDI closure system. This paper mainly focuses on the fundamen?tal components of MDI container closure system,analyzes leachable sources and safety information and reviews the related contents about leachable studies in domestic and foreign pharmacopoeia.
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The container closure system is indispensable to metered-dose inhaler (MDI). In the shelf life of MDI, various ingredients of the container closure system may become potential leachables and migrate into the preparation. Due to their unknown constructs and latent ambiguous toxicities, leachables may significantly affect drugs’ effectiveness and safety. Consequently, it is necessary to carry on leachable studies to ensure the good compatibility of MDI closure system. This paper mainly focuses on the fundamental components of MDI container closure system, analyzes leachable sources and safety information and reviews the related contents about leachable studies in domestic and foreign pharmacopoeia.
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Objective To observe the technical feasibility and safety of delta -shaped (DS)anastomosis in totally laparoscopic distal gastrectomy (TLDG).Methods A retrospective analysis of 9 cases underwent TLDG with D2 lymphadenectomy and DS anastomosis.Results All the patients underwent TLDG with D2 lymphadenectomy and DS anastomosis successfully by the same doctor and his team.The total operative time was (178 ±43)minutes,and the DS anastomosis time was (32 ±8)minutes.All the patients achieved microscopic cancer -free margin and the number of lymph nodes harvested was (27 ±8)per patient.The average time to flatus,time to fluid diet were (3.8 ± 1.7)days and (3.9 ±1.8)days respectivly.One patient developed to fat liquefaction of incision,and one developed to urinary tract infection after the operation.No anastomotic bleeding,anastomotic leakage,anastomotic stenosis or other anastomotic complications happened among all patients.Conclusion DS anastomosis is safe and convenient.It is an ideal choice for reconstruction in TLDG with D2 lymphadenectomy.
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Objective To explore the effect of cisapride combined with polyethylene glycol electrolytic solution on preoperative bowel preparation for patients receiving colorectal cancer operation. Methods One hundred and fifty-two patients received colorectal cancer opera-tion in our hospital from October 2010 to October 2014 were selected. Those who were treated with cisapride combined with polyethylene gly-col electrolytic solution for bowel preparation before operation were assigned to oberservation group(n=83),those who were treated with poly-ethylene glycol electrolytic solution for bowel preparation before operation were assigned to control group(n=69). The side effect after medi-cation, electrolyte concentration and incidence of incision infection between groups after operation were collected and compared. Results The incidence of nausea and vomiting was 7. 23% in observation group,which was significantly lower than 18. 84% in control group (χ2 =4. 64,P=0. 03). The difference of Na+,K+ and Cl- concentration between groups were not significant (t=1. 83,P=0. 07;t=0. 42,P=0. 68;t=1. 86,P=0. 07). The body temperature,leukocyte count and incidence of incision infection after operation in observation group were significantly lower than those in control group (t=2. 68,P<0. 01;t=3. 29,P<0. 01;χ2 =4. 90,P=0. 03). Conclusion Cisapride com-bined with polyethylene glycol electrolytic solution before operation can significantly decrease the incidence of gastrointestinal side effect after medicaiton and incision infection after operation and it is beneficial to recovery for patients with colorectal cancer operation.
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The data analysis of food supervision needs to reflect the integration of food safety and possible trend based on the fun-damental test data of stressed foods and their products. With the assessment and analysis on potential resources of hazard elements, the integrate management support of food safety could be achieved. The data management could be organized and evaluated through plan, collection, treatment and display, which might be assisted to establish data-link with process mining to enforce the prospect of food safety background and trend and to provide the support of food safety management.
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Objective:To evaluate the common nursing problems in pharmacy intravenous admixture services(PIVAS).Methods:By strengthening nursing staff training,nurses were required to carry out checking system strictly,use the super-clean work platform collectly and prevent minute granule contamination.Results:Among 170 000 pack of intravenous liquid prepared in PIVAS in the last six months,no transfusion reaction occurred.Medical cost decreased and nursing occupation protection was strengthened.Conclusion:Strict Personal and system management can guarantee the effectiveness of PIVAS.
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Infection is one of the most serious complications of acupuncture. But no infection ever appears without contamination, so the best method for preventing infection is to avoid contamination.<BR>There are two causes of contamination by acupuncture, namely, unsatisfactory disinfection of skin and contaminated neeedles. The former involves incomplete skin cleaning and inadequate disinfection. The latter is caused by contact with unsanitary matter. Some factors which are usually considered insignificant, such as contamination by needle tube, finger push technique, needle insertion technique or contamination in the needle case, should be re-examined.<BR>The author never touches the part of the needle which can penetrate the skin. This simple measure can help to prevent contamination of needles and consequent infection.